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MBL Life Sciences
| Product Specifications | |
| Application | WB |
| Reactivity | Human |
| Clonality | Monoclonal IgG1 ĸ |
| Host | Mouse |
| Immunogen | Recombinant human TX N-terminal amino acids (1-270aa) |
| Gene ID - Human | |
| Formulation | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained. |
| Storage | -20C |
| Documents & Links for Anti-Caspase-4 (Human) mAb (Clone: 4B9) | |
| Datasheet | Anti-Caspase-4 (Human) mAb (Clone: 4B9) Datasheet |
| Documents & Links for Anti-Caspase-4 (Human) mAb (Clone: 4B9) | |
| Datasheet | Anti-Caspase-4 (Human) mAb (Clone: 4B9) Datasheet |
| Citations for Anti-Caspase-4 (Human) mAb (Clone: 4B9) – 27 Found |
| Lin, X Y; Choi, M S; Porter, A G. Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma. The Journal Of Biological Chemistry. 2000;275(51):39920-6. PubMed - Comments: Used in: WB |
| Hitomi, Junichi; Katayama, Taiichi; Eguchi, Yutaka; Kudo, Takashi; Taniguchi, Manabu; Koyama, Yoshihisa; Manabe, Takayuki; Yamagishi, Satoru; Bando, Yoshio; Imaizumi, Kazunori; Tsujimoto, Yoshihide; Tohyama, Masaya. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. The Journal Of Cell Biology. 2004;165(3):347-56. PubMed - Comments: Used in: WB |
| Milleron, Rania S; Bratton, Shawn B. Heat shock induces apoptosis independently of any known initiator caspase-activating complex. The Journal Of Biological Chemistry. 2006;281(25):16991-17000. PubMed - Comments: Used in: WB |
| Yukioka, Futoshi; Matsuzaki, Shinsuke; Kawamoto, Keisuke; Koyama, Yoshihisa; Hitomi, Junichi; Katayama, Taiichi; Tohyama, Masaya. Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis. Neurochemistry International. 2008;52(4-5):683-7. PubMed - Comments: Used in: WB |
| Oda, Tetsuro; Kosuge, Yasuhiro; Arakawa, Motoki; Ishige, Kumiko; Ito, Yoshihisa. Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells. Neuroscience Research. 2008;60(1):29-39. PubMed - Comments: Used in: WB |
| Koyama, Yoshihisa; Matsuzaki, Shinsuke; Gomi, Fumi; Yamada, Kohei; Katayama, Taiichi; Sato, Kohji; Kumada, Tatsuro; Fukuda, Atsuo; Matsuda, Satoshi; Tano, Yasuo; Tohyama, Masaya. Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells. Investigative Ophthalmology & Visual Science. 2008;49(6):2376-83. PubMed - Comments: Used in: WB |
| Pastorino, John G; Shulga, Nataly. Tumor necrosis factor-alpha can provoke cleavage and activation of sterol regulatory element-binding protein in ethanol-exposed cells via a caspase-dependent pathway that is cholesterol insensitive. The Journal Of Biological Chemistry. 2008;283(37):25638-25649. PubMed - Comments: Used in: WB |
| Nawrocki, Steffan T; Carew, Jennifer S; Maclean, Kirsteen H; Courage, James F; Huang, Peng; Houghton, Janet A; Cleveland, John L; Giles, Francis J; McConkey, David J. Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood. 2008;112(7):2917-26. PubMed - Comments: Used in: WB |
| Nishitsuji, Kazuchika; Tomiyama, Takami; Ishibashi, Kenichi; Ito, Kazuhiro; Teraoka, Rie; Lambert, Mary P; Klein, William L; Mori, Hiroshi. The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. The American Journal Of Pathology. 2009;174(3):957-69. PubMed - Comments: Used in: WB |
| Koyama, Yoshihisa; Hiratsuka, Toru; Matsuzaki, Shinsuke; Yamagishi, Satoru; Kato, Shinsuke; Katayama, Taiichi; Tohyama, Masaya. Familial amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS. Neurochemistry International. 2010;57(7):838-43. PubMed - Comments: Used in: WB |
| Hiratsuka, Toru; Matsuzaki, Shinsuke; Miyata, Shingo; Kinoshita, Mitsuhiro; Kakehi, Kazuaki; Nishida, Shinji; Katayama, Taiichi; Tohyama, Masaya. Yokukansan inhibits neuronal death during ER stress by regulating the unfolded protein response. Plos One. 2010;5(10):e13280. PubMed - Comments: Used in: WB |
| Takemoto, Kana; Miyata, Shingo; Takamura, Hironori; Katayama, Taiichi; Tohyama, Masaya. Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum. Neurochemistry International. 2011;58(8):880-7. PubMed - Comments: Used in: WB |
| Huang, Tsung-Teng; Liu, Fu-Guo; Wei, Chia-Fong; Lu, Chia-Chen; Chen, Chang-Chieh; Lin, Hung-Chi; Ojcius, David M; Lai, Hsin-Chih. Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin. Plos One. 2011;6(4):e18308. PubMed - Comments: Used in: WB |
| Friedman, S M. The relation of cell volume, cell sodium and the transmembrane sodium gradient to blood pressure. Journal Of Hypertension. 1990;8(1):67-73. PubMed - Comments: Used in: WB |
| Ito, Kentaro; Takahashi, Akinori; Morita, Masahiro; Suzuki, Toru; Yamamoto, Tadashi. The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability. Protein & Cell. 2011;2(9):755-63. PubMed - Comments: Used in: WB |
| Yoshikawa, Tadanobu; Ogata, Nahoko; Izuta, Hiroshi; Shimazawa, Masamitsu; Hara, Hideaki; Takahashi, Kanji. Increased expression of tight junctions in ARPE-19 cells under endoplasmic reticulum stress. Current Eye Research. 2011;36(12):1153-63. PubMed - Comments: Used in: WB |
| Michallet, Anne-Sophie; Mondiere, Paul; Taillardet, Morgan; Leverrier, Yann; Genestier, Laurent; Defrance, Thierry. Compromising the unfolded protein response induces autophagy-mediated cell death in multiple myeloma cells. Plos One. 6(10):e25820. PubMed - Comments: Used in: WB |
| Sollberger, Gabriel; Strittmatter, Gerhard E; Kistowska, Magdalena; French, Lars E; Beer, Hans-Dietmar. Caspase-4 is required for activation of inflammasomes. Journal Of Immunology (Baltimore, Md. : 1950). 2012;188(4):1992-2000. PubMed - Comments: Used in: WB |
| Kajiwara, Yuji; Schiff, Tamar; Voloudakis, Georgios; Gama Sosa, Miguel A; Elder, Gregory; Bozdagi, Ozlem; Buxbaum, Joseph D. A critical role for human caspase-4 in endotoxin sensitivity. Journal Of Immunology (Baltimore, Md. : 1950). 2014;193(1):335-43. PubMed - Comments: Used in: WB |
| Shi, Jianjin; Zhao, Yue; Wang, Yupeng; Gao, Wenqing; Ding, Jingjin; Li, Peng; Hu, Liyan; Shao, Feng. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514(7521):187-92. PubMed - Comments: Used in: WB |
| Flood, B; Oficjalska, K; Laukens, D; Fay, J; O'Grady, A; Caiazza, F; Heetun, Z; Mills, K H G; Sheahan, K; Ryan, E J; Doherty, G A; Kay, E; Creagh, E M. Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential. Clinical And Experimental Immunology. 2015;181(1):39-50. PubMed - Comments: Used in: WB |
| Flood, B; Oficjalska, K; Laukens, D; Fay, J; O'Grady, A; Caiazza, F; Heetun, Z; Mills, K H G; Sheahan, K; Ryan, E J; Doherty, G A; Kay, E; Creagh, E M. Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential. Clinical And Experimental Immunology. 2015;181(1):39-50. PubMed - Comments: Used in: IHC |
| Gualdoni, Guido A; Lingscheid, Tilman; Schmetterer, Klaus G; Hennig, Annika; Steinberger, Peter; Zlabinger, Gerhard J. Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation. Scientific Reports. 2015;5:12016. PubMed - Comments: Used in: WB |
| Aachoui, Youssef; Kajiwara, Yuji; Leaf, Irina A; Mao, Dat; Ting, Jenny P-Y; Coers, Jörn; Aderem, Alan; Buxbaum, Joseph D; Miao, Edward A. Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host & Microbe. 2015;18(3):320-32. PubMed - Comments: Used in: WB |
| Cheng, Xi; Feng, Haoran; Wu, Haoxuan; Jin, Zhijian; Shen, Xiaonan; Kuang, Jie; Huo, Zhen; Chen, Xianze; Gao, Haoji; Ye, Feng; Ji, Xiaopin; Jing, Xiaoqian; Zhang, Yaqi; Zhang, Tao; Qiu, Weihua; Zhao, Ren. Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer. Cancer Letters. 2018;431:105-114. PubMed - Comments: Used in: WB |
| Platnich, Jaye M; Chung, Hyunjae; Lau, Arthur; Sandall, Christina F; Bondzi-Simpson, Adom; Chen, Huey-Miin; Komada, Takanori; Trotman-Grant, Aaron C; Brandelli, Jeremy R; Chun, Justin; Beck, Paul L; Philpott, Dana J; Girardin, Stephen E; Ho, May; Johnson, Roger P; MacDonald, Justin A; Armstrong, Glen D; Muruve, Daniel A. Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Cell Reports. 2018;25(6):1525-1536.e7. PubMed - Comments: Used in: WB |
| Zasłona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M; Carroll, Richard G; Palsson-McDermott, Eva M; Hughes, Mark M; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd; McElvaney, Oliver J; Mills, Kingston H G; Lavelle, Ed C; Wygrecka, Małgorzata; Creagh, Emma M; O'Neill, Luke A J. Caspase-11 promotes allergic airway inflammation. Nature Communications. 2020;11(1):1055. PubMed - Comments: Used in: WB |
MBL Life Sciences
| Product Specifications | |
| Application | WB |
| Reactivity | Human |
| Clonality | Monoclonal IgG1 ĸ |
| Host | Mouse |
| Immunogen | Recombinant human TX N-terminal amino acids (1-270aa) |
| Gene ID - Human | |
| Formulation | 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained. |
| Storage | -20C |
| Documents & Links for Anti-Caspase-4 (Human) mAb (Clone: 4B9) | |
| Datasheet | Anti-Caspase-4 (Human) mAb (Clone: 4B9) Datasheet |
| Documents & Links for Anti-Caspase-4 (Human) mAb (Clone: 4B9) | |
| Datasheet | Anti-Caspase-4 (Human) mAb (Clone: 4B9) Datasheet |
| Citations for Anti-Caspase-4 (Human) mAb (Clone: 4B9) – 27 Found |
| Lin, X Y; Choi, M S; Porter, A G. Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-gamma. The Journal Of Biological Chemistry. 2000;275(51):39920-6. PubMed - Comments: Used in: WB |
| Hitomi, Junichi; Katayama, Taiichi; Eguchi, Yutaka; Kudo, Takashi; Taniguchi, Manabu; Koyama, Yoshihisa; Manabe, Takayuki; Yamagishi, Satoru; Bando, Yoshio; Imaizumi, Kazunori; Tsujimoto, Yoshihide; Tohyama, Masaya. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. The Journal Of Cell Biology. 2004;165(3):347-56. PubMed - Comments: Used in: WB |
| Milleron, Rania S; Bratton, Shawn B. Heat shock induces apoptosis independently of any known initiator caspase-activating complex. The Journal Of Biological Chemistry. 2006;281(25):16991-17000. PubMed - Comments: Used in: WB |
| Yukioka, Futoshi; Matsuzaki, Shinsuke; Kawamoto, Keisuke; Koyama, Yoshihisa; Hitomi, Junichi; Katayama, Taiichi; Tohyama, Masaya. Presenilin-1 mutation activates the signaling pathway of caspase-4 in endoplasmic reticulum stress-induced apoptosis. Neurochemistry International. 2008;52(4-5):683-7. PubMed - Comments: Used in: WB |
| Oda, Tetsuro; Kosuge, Yasuhiro; Arakawa, Motoki; Ishige, Kumiko; Ito, Yoshihisa. Distinct mechanism of cell death is responsible for tunicamycin-induced ER stress in SK-N-SH and SH-SY5Y cells. Neuroscience Research. 2008;60(1):29-39. PubMed - Comments: Used in: WB |
| Koyama, Yoshihisa; Matsuzaki, Shinsuke; Gomi, Fumi; Yamada, Kohei; Katayama, Taiichi; Sato, Kohji; Kumada, Tatsuro; Fukuda, Atsuo; Matsuda, Satoshi; Tano, Yasuo; Tohyama, Masaya. Induction of amyloid beta accumulation by ER calcium disruption and resultant upregulation of angiogenic factors in ARPE19 cells. Investigative Ophthalmology & Visual Science. 2008;49(6):2376-83. PubMed - Comments: Used in: WB |
| Pastorino, John G; Shulga, Nataly. Tumor necrosis factor-alpha can provoke cleavage and activation of sterol regulatory element-binding protein in ethanol-exposed cells via a caspase-dependent pathway that is cholesterol insensitive. The Journal Of Biological Chemistry. 2008;283(37):25638-25649. PubMed - Comments: Used in: WB |
| Nawrocki, Steffan T; Carew, Jennifer S; Maclean, Kirsteen H; Courage, James F; Huang, Peng; Houghton, Janet A; Cleveland, John L; Giles, Francis J; McConkey, David J. Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood. 2008;112(7):2917-26. PubMed - Comments: Used in: WB |
| Nishitsuji, Kazuchika; Tomiyama, Takami; Ishibashi, Kenichi; Ito, Kazuhiro; Teraoka, Rie; Lambert, Mary P; Klein, William L; Mori, Hiroshi. The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. The American Journal Of Pathology. 2009;174(3):957-69. PubMed - Comments: Used in: WB |
| Koyama, Yoshihisa; Hiratsuka, Toru; Matsuzaki, Shinsuke; Yamagishi, Satoru; Kato, Shinsuke; Katayama, Taiichi; Tohyama, Masaya. Familial amyotrophic lateral sclerosis (FALS)-linked SOD1 mutation accelerates neuronal cell death by activating cleavage of caspase-4 under ER stress in an in vitro model of FALS. Neurochemistry International. 2010;57(7):838-43. PubMed - Comments: Used in: WB |
| Hiratsuka, Toru; Matsuzaki, Shinsuke; Miyata, Shingo; Kinoshita, Mitsuhiro; Kakehi, Kazuaki; Nishida, Shinji; Katayama, Taiichi; Tohyama, Masaya. Yokukansan inhibits neuronal death during ER stress by regulating the unfolded protein response. Plos One. 2010;5(10):e13280. PubMed - Comments: Used in: WB |
| Takemoto, Kana; Miyata, Shingo; Takamura, Hironori; Katayama, Taiichi; Tohyama, Masaya. Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum. Neurochemistry International. 2011;58(8):880-7. PubMed - Comments: Used in: WB |
| Huang, Tsung-Teng; Liu, Fu-Guo; Wei, Chia-Fong; Lu, Chia-Chen; Chen, Chang-Chieh; Lin, Hung-Chi; Ojcius, David M; Lai, Hsin-Chih. Activation of multiple apoptotic pathways in human nasopharyngeal carcinoma cells by the prenylated isoflavone, osajin. Plos One. 2011;6(4):e18308. PubMed - Comments: Used in: WB |
| Friedman, S M. The relation of cell volume, cell sodium and the transmembrane sodium gradient to blood pressure. Journal Of Hypertension. 1990;8(1):67-73. PubMed - Comments: Used in: WB |
| Ito, Kentaro; Takahashi, Akinori; Morita, Masahiro; Suzuki, Toru; Yamamoto, Tadashi. The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability. Protein & Cell. 2011;2(9):755-63. PubMed - Comments: Used in: WB |
| Yoshikawa, Tadanobu; Ogata, Nahoko; Izuta, Hiroshi; Shimazawa, Masamitsu; Hara, Hideaki; Takahashi, Kanji. Increased expression of tight junctions in ARPE-19 cells under endoplasmic reticulum stress. Current Eye Research. 2011;36(12):1153-63. PubMed - Comments: Used in: WB |
| Michallet, Anne-Sophie; Mondiere, Paul; Taillardet, Morgan; Leverrier, Yann; Genestier, Laurent; Defrance, Thierry. Compromising the unfolded protein response induces autophagy-mediated cell death in multiple myeloma cells. Plos One. 6(10):e25820. PubMed - Comments: Used in: WB |
| Sollberger, Gabriel; Strittmatter, Gerhard E; Kistowska, Magdalena; French, Lars E; Beer, Hans-Dietmar. Caspase-4 is required for activation of inflammasomes. Journal Of Immunology (Baltimore, Md. : 1950). 2012;188(4):1992-2000. PubMed - Comments: Used in: WB |
| Kajiwara, Yuji; Schiff, Tamar; Voloudakis, Georgios; Gama Sosa, Miguel A; Elder, Gregory; Bozdagi, Ozlem; Buxbaum, Joseph D. A critical role for human caspase-4 in endotoxin sensitivity. Journal Of Immunology (Baltimore, Md. : 1950). 2014;193(1):335-43. PubMed - Comments: Used in: WB |
| Shi, Jianjin; Zhao, Yue; Wang, Yupeng; Gao, Wenqing; Ding, Jingjin; Li, Peng; Hu, Liyan; Shao, Feng. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 2014;514(7521):187-92. PubMed - Comments: Used in: WB |
| Flood, B; Oficjalska, K; Laukens, D; Fay, J; O'Grady, A; Caiazza, F; Heetun, Z; Mills, K H G; Sheahan, K; Ryan, E J; Doherty, G A; Kay, E; Creagh, E M. Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential. Clinical And Experimental Immunology. 2015;181(1):39-50. PubMed - Comments: Used in: WB |
| Flood, B; Oficjalska, K; Laukens, D; Fay, J; O'Grady, A; Caiazza, F; Heetun, Z; Mills, K H G; Sheahan, K; Ryan, E J; Doherty, G A; Kay, E; Creagh, E M. Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential. Clinical And Experimental Immunology. 2015;181(1):39-50. PubMed - Comments: Used in: IHC |
| Gualdoni, Guido A; Lingscheid, Tilman; Schmetterer, Klaus G; Hennig, Annika; Steinberger, Peter; Zlabinger, Gerhard J. Azithromycin inhibits IL-1 secretion and non-canonical inflammasome activation. Scientific Reports. 2015;5:12016. PubMed - Comments: Used in: WB |
| Aachoui, Youssef; Kajiwara, Yuji; Leaf, Irina A; Mao, Dat; Ting, Jenny P-Y; Coers, Jörn; Aderem, Alan; Buxbaum, Joseph D; Miao, Edward A. Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host & Microbe. 2015;18(3):320-32. PubMed - Comments: Used in: WB |
| Cheng, Xi; Feng, Haoran; Wu, Haoxuan; Jin, Zhijian; Shen, Xiaonan; Kuang, Jie; Huo, Zhen; Chen, Xianze; Gao, Haoji; Ye, Feng; Ji, Xiaopin; Jing, Xiaoqian; Zhang, Yaqi; Zhang, Tao; Qiu, Weihua; Zhao, Ren. Targeting autophagy enhances apatinib-induced apoptosis via endoplasmic reticulum stress for human colorectal cancer. Cancer Letters. 2018;431:105-114. PubMed - Comments: Used in: WB |
| Platnich, Jaye M; Chung, Hyunjae; Lau, Arthur; Sandall, Christina F; Bondzi-Simpson, Adom; Chen, Huey-Miin; Komada, Takanori; Trotman-Grant, Aaron C; Brandelli, Jeremy R; Chun, Justin; Beck, Paul L; Philpott, Dana J; Girardin, Stephen E; Ho, May; Johnson, Roger P; MacDonald, Justin A; Armstrong, Glen D; Muruve, Daniel A. Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Cell Reports. 2018;25(6):1525-1536.e7. PubMed - Comments: Used in: WB |
| Zasłona, Zbigniew; Flis, Ewelina; Wilk, Mieszko M; Carroll, Richard G; Palsson-McDermott, Eva M; Hughes, Mark M; Diskin, Ciana; Banahan, Kathy; Ryan, Dylan G; Hooftman, Alexander; Misiak, Alicja; Kearney, Jay; Lochnit, Gunter; Bertrams, Wilhelm; Greulich, Timm; Schmeck, Bernd; McElvaney, Oliver J; Mills, Kingston H G; Lavelle, Ed C; Wygrecka, Małgorzata; Creagh, Emma M; O'Neill, Luke A J. Caspase-11 promotes allergic airway inflammation. Nature Communications. 2020;11(1):1055. PubMed - Comments: Used in: WB |
