Background

Prohibitin2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory 
activities of antiestrogens and represses the activity of estrogens. It probably involves in regulating mitochondrial respiration activity and in aging.

References

1) Sun et al. (2011) CaMK IV phosphorylates prohibitin 2 and regulates prohibitin 2-mediated repression of MEF2 transcription. Cell Signal. 23:1686-1690.