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Cosmo Bio
Cosmo Bio
TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and
tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral
sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of
human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa)
and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases.
These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases
and for evaluation of cellular or animal models of TDP-43 proteinopathy.
| Product Specifications | |
| Application | ELISA, IHC, WB |
| Reactivity | Rat, Human |
| Clonality | Polyclonal |
| Host | Rabbit |
| Documents & Links for Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) | |
| Datasheet | Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) Datasheet |
| Flyer | Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) Flyer |
| Documents & Links for Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) | |
| Datasheet | Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) Datasheet |
| Flyer | Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) Flyer |
| Citations for Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) – 1 Found |
| Kawahara, Yukio; Mieda-Sato, Ai. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2012;109(9):3347-52. PubMed |
TDP-43, a heterogeneous nuclear ribonucleoprotein, was identified as a component of ubiquitin-positive and
tau-negative inclusions observed in cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral
sclerosis (ALS). Immunochemical analyses using antibodies generated against phospho- and non-phosphopeptides of
human TDP-43 revealed that abnormally phosphorylated full-length TDP-43 (45 kDa), C-terminal fragments (~25 kDa)
and smearing substances are deposited as intracellular inclusions in affected regions of FTLD-U and ALS cases.
These antibodies are powerful tools for biochemical and immunohistochemical analyses of neurodegenerative diseases
and for evaluation of cellular or animal models of TDP-43 proteinopathy.
| Product Specifications | |
| Application | ELISA, IHC, WB |
| Reactivity | Rat, Human |
| Clonality | Polyclonal |
| Host | Rabbit |
| Documents & Links for Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) | |
| Datasheet | Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) Datasheet |
| Flyer | Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) Flyer |
| Documents & Links for Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) | |
| Datasheet | Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) Datasheet |
| Flyer | Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) Flyer |
| Citations for Anti TAR DNA-binding protein 43 (TDP-43) Amino Acids 3-12 pAb (Rabbit, Antiserum) – 1 Found |
| Kawahara, Yukio; Mieda-Sato, Ai. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2012;109(9):3347-52. PubMed |
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