WDR45L is a ubiquitously expressed WD40 repeat protein upregulated in a variety of tumor tissues including ovarian and uterine cancers. WDR45L, also known as WIPI-3, comprises seven 40 amino acid (WD40) repeats. WD40 repeats are found in many eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in multiple functions, including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. This protein regulates cell cycle transcription and signal transduction, and it is believed to be involved in cell death by apoptosis and autophagy. In recent years, it has also been used as a marker for neurodegenerative diseases associated with cell death.