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Cosmo Bio
Cosmo Bio




Lactobacillus paracasei is an obligate heterofermentative lactic acid bacterium isolated from a wide range of sources, including plant-based fermented foods and fermented milk products. It has attracted attention for its immune-modulating activity. This product contains a purified extracellular vesicle (EV) fraction obtained by ultrafiltration of the culture supernatant of Lactobacillus paracasei. This lactic acid bacterium was independently isolated, cultured, and identified by Professor Akihiro Yamaguchi and laboratory student Kurumi Kameda of the Laboratory of Applied Microbiology, Rakuno Gakuen University, from on-campus plant materials and Hokkaido-produced ingredients. The electron micrograph was taken by Professor Tomohito Iwasaki of the Laboratory of Applied Biochemistry at the same university.
| Documents & Links for Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain | |
| Datasheet | Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain Datasheet |
| Documents & Links for Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain | |
| Datasheet | Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain Datasheet |
| Citations for Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain – 2 Found |
| Kimiko Minamida, Toshio Taira, Masato Sasaki, Ohki Higuchi, Xian-Ying Meng, Yoichi Kamagata, Kazunori Miwa. Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro. Bioscience, Biotechnology, and Biochemistry. 2024;88(3):333–343. PubMed |
| Kyle Haasbroek, Shino Otaka, Chieko Sakiyama, Shohei Iwase, Masayuki Yagi, Yoshikazu Yonei. Extracellular vesicles from probiotic microorganisms enhance microglia amyloid β phagocytosis. Glycative Stress Research. 2024;88(3) |




Lactobacillus paracasei is an obligate heterofermentative lactic acid bacterium isolated from a wide range of sources, including plant-based fermented foods and fermented milk products. It has attracted attention for its immune-modulating activity. This product contains a purified extracellular vesicle (EV) fraction obtained by ultrafiltration of the culture supernatant of Lactobacillus paracasei. This lactic acid bacterium was independently isolated, cultured, and identified by Professor Akihiro Yamaguchi and laboratory student Kurumi Kameda of the Laboratory of Applied Microbiology, Rakuno Gakuen University, from on-campus plant materials and Hokkaido-produced ingredients. The electron micrograph was taken by Professor Tomohito Iwasaki of the Laboratory of Applied Biochemistry at the same university.
| Documents & Links for Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain | |
| Datasheet | Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain Datasheet |
| Documents & Links for Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain | |
| Datasheet | Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain Datasheet |
| Citations for Extracellular Vesicles derived from Lactobacillus paracasei 180913-R1 strain – 2 Found |
| Kimiko Minamida, Toshio Taira, Masato Sasaki, Ohki Higuchi, Xian-Ying Meng, Yoichi Kamagata, Kazunori Miwa. Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro. Bioscience, Biotechnology, and Biochemistry. 2024;88(3):333–343. PubMed |
| Kyle Haasbroek, Shino Otaka, Chieko Sakiyama, Shohei Iwase, Masayuki Yagi, Yoshikazu Yonei. Extracellular vesicles from probiotic microorganisms enhance microglia amyloid β phagocytosis. Glycative Stress Research. 2024;88(3) |