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Cosmo Bio
Hyaluronan oligosaccharides are known for their various activities depending on the size as reported by Stern R. et al1). Hyaluronan oligosaccharides are made by an enzyme, hyaluronidase, from hyaluronan polymer extracted from rooster comb or isolated from fermentation products of bacteria. There is a difference between the structure of hyaluronan oligosaccharides made by manmmalian enzymes and by bacterial enzymes.
Oligosaccharides made by hyaluronidase derived from bacteria are called “unsaturated” oligosaccharides because of the double bond between the C-4 and C-5 position of uronic acid at their non-reducing end. On the other hand, oligosaccharides made by hyaluronidase derived from mammalian testis are called “saturated” oligosaccharides because they have no unsaturated bonds. This product is made from hyaluronan polymer purified from fermentation products of streptococcus sp, by digestion with mammalian hyaluronidase derived from ovine testis, and purified by column chromatography2).
| Hyaluronan Oligosaccharide Ordering Information | Catalog No. |
| Hyaluronan oligosaccharide assortment (HA4, HA6, HA8, HA10, HA12) | CSR-93001 |
| Hyaluronan oligosaccharide assortment (HA4, HA6, HA8, HA10, HA12), Endotoxin Free | CSR-93002 |
| Hyaluronan Oligosaccharide 4mer (HA4) | CSR-11001 |
| Hyaluronan Oligosaccharide 4mer (HA4), Endotoxin Free | CSR-11006 |
| Hyaluronan Oligosaccharide 6mer (HA6) | CSR-11002 |
| Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free | CSR-11007 |
| Hyaluronan Oligosaccharide 8mer (HA8) | CSR-11003 |
| Hyaluronan Oligosaccharide 8mer (HA8), Endotoxin Free | CSR-11008 |
| Hyaluronan Oligosaccharide 10mer (HA10) | CSR-11004 |
| Hyaluronan Oligosaccharide 10mer (HA10), Endotoxin Free | CSR-11009 |
| Hyaluronan Oligosaccharide 12mer (HA12) | CSR-11005 |
| Hyaluronan Oligosaccharide 12mer (HA12), Endotoxin Free | CSR-11010 |
1) Stern R, et al.: Eur J Cell Biol, 85, 699 (2006)
2) Tawada A, et al.: Glycobiology, 12, 421 (2002)
| Documents & Links for Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free | |
| Datasheet | Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free Datasheet |
| Documents & Links for Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free | |
| Datasheet | Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free Datasheet |
| Citations for Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free – 3 Found |
| Campo, Giuseppe M; Avenoso, Angela; Campo, Salvatore; D'Ascola, Angela; Nastasi, Giancarlo; Calatroni, Alberto. Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes. Biochemical Pharmacology. 2010;80(4):480-90. PubMed |
| Robert Stern 1, Akira A Asari, Kazuki N Sugahara. Hyaluronan fragments: an information-rich system. Eur J Cell Biol . . 2006;:85(8):699-715. |
| Akira Tawada 1, Takahiro Masa, Yoji Oonuki, Atsushi Watanabe, Yuji Matsuzaki, Akira Asari. Large-scale preparation, purification, and characterization of hyaluronan oligosaccharides from 4-mers to 52-mers. Glycobiology .. 2002;:(7):421-6. |
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Cosmo Bio
Hyaluronan oligosaccharides are known for their various activities depending on the size as reported by Stern R. et al1). Hyaluronan oligosaccharides are made by an enzyme, hyaluronidase, from hyaluronan polymer extracted from rooster comb or isolated from fermentation products of bacteria. There is a difference between the structure of hyaluronan oligosaccharides made by manmmalian enzymes and by bacterial enzymes.
Oligosaccharides made by hyaluronidase derived from bacteria are called “unsaturated” oligosaccharides because of the double bond between the C-4 and C-5 position of uronic acid at their non-reducing end. On the other hand, oligosaccharides made by hyaluronidase derived from mammalian testis are called “saturated” oligosaccharides because they have no unsaturated bonds. This product is made from hyaluronan polymer purified from fermentation products of streptococcus sp, by digestion with mammalian hyaluronidase derived from ovine testis, and purified by column chromatography2).
| Hyaluronan Oligosaccharide Ordering Information | Catalog No. |
| Hyaluronan oligosaccharide assortment (HA4, HA6, HA8, HA10, HA12) | CSR-93001 |
| Hyaluronan oligosaccharide assortment (HA4, HA6, HA8, HA10, HA12), Endotoxin Free | CSR-93002 |
| Hyaluronan Oligosaccharide 4mer (HA4) | CSR-11001 |
| Hyaluronan Oligosaccharide 4mer (HA4), Endotoxin Free | CSR-11006 |
| Hyaluronan Oligosaccharide 6mer (HA6) | CSR-11002 |
| Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free | CSR-11007 |
| Hyaluronan Oligosaccharide 8mer (HA8) | CSR-11003 |
| Hyaluronan Oligosaccharide 8mer (HA8), Endotoxin Free | CSR-11008 |
| Hyaluronan Oligosaccharide 10mer (HA10) | CSR-11004 |
| Hyaluronan Oligosaccharide 10mer (HA10), Endotoxin Free | CSR-11009 |
| Hyaluronan Oligosaccharide 12mer (HA12) | CSR-11005 |
| Hyaluronan Oligosaccharide 12mer (HA12), Endotoxin Free | CSR-11010 |
1) Stern R, et al.: Eur J Cell Biol, 85, 699 (2006)
2) Tawada A, et al.: Glycobiology, 12, 421 (2002)
| Documents & Links for Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free | |
| Datasheet | Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free Datasheet |
| Documents & Links for Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free | |
| Datasheet | Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free Datasheet |
| Citations for Hyaluronan Oligosaccharide 6mer (HA6), Endotoxin Free – 3 Found |
| Campo, Giuseppe M; Avenoso, Angela; Campo, Salvatore; D'Ascola, Angela; Nastasi, Giancarlo; Calatroni, Alberto. Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes. Biochemical Pharmacology. 2010;80(4):480-90. PubMed |
| Robert Stern 1, Akira A Asari, Kazuki N Sugahara. Hyaluronan fragments: an information-rich system. Eur J Cell Biol . . 2006;:85(8):699-715. |
| Akira Tawada 1, Takahiro Masa, Yoji Oonuki, Atsushi Watanabe, Yuji Matsuzaki, Akira Asari. Large-scale preparation, purification, and characterization of hyaluronan oligosaccharides from 4-mers to 52-mers. Glycobiology .. 2002;:(7):421-6. |