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Hakarel
Hakarel
Immune checkpoint blockade therapies targeting programmed cell death protein 1 (PD-1) achieve marked clinical benefits in cancer patients harboring programmed death ligand-1 (PD-L1) expression tumors. PD-L2 was confirmed highly expressed in HNSCC, salivary gland cancer (SGC), prostate cancer, gastric cancer, colorectal cancer, oesophageal adenocarcinoma, and bladder cancer. Although the structure of PD-L2 is similar to PD-L1, the binding affinity between PD-L2 and PD-1 is two- to sixfold higher than that with PD-L1, suggesting PD-L2 is an important molecule in immune escape as the strong interaction inhibits cytokines secretion and proliferation of T cells. These findings open a new era to understand the function of PD-L2 and provide new insights for improving the efficiency of anti-PD-1 therapy. 1)
This kit detects human PD-L2 by a two-step sandwich method using the high-performance antibody against human PD-L2, an immune checkpoint related molecule.
Please Note: This product is manufactured upon receipt of order. Delivery time is 3 to 4 weeks.
| Documents & Links for PD-L2 ELISA Kit, Human | |
| Datasheet | PD-L2 ELISA Kit, Human Datasheet |
| Documents & Links for PD-L2 ELISA Kit, Human | |
| Datasheet | PD-L2 ELISA Kit, Human Datasheet |
Immune checkpoint blockade therapies targeting programmed cell death protein 1 (PD-1) achieve marked clinical benefits in cancer patients harboring programmed death ligand-1 (PD-L1) expression tumors. PD-L2 was confirmed highly expressed in HNSCC, salivary gland cancer (SGC), prostate cancer, gastric cancer, colorectal cancer, oesophageal adenocarcinoma, and bladder cancer. Although the structure of PD-L2 is similar to PD-L1, the binding affinity between PD-L2 and PD-1 is two- to sixfold higher than that with PD-L1, suggesting PD-L2 is an important molecule in immune escape as the strong interaction inhibits cytokines secretion and proliferation of T cells. These findings open a new era to understand the function of PD-L2 and provide new insights for improving the efficiency of anti-PD-1 therapy. 1)
This kit detects human PD-L2 by a two-step sandwich method using the high-performance antibody against human PD-L2, an immune checkpoint related molecule.
Please Note: This product is manufactured upon receipt of order. Delivery time is 3 to 4 weeks.
| Documents & Links for PD-L2 ELISA Kit, Human | |
| Datasheet | PD-L2 ELISA Kit, Human Datasheet |
| Documents & Links for PD-L2 ELISA Kit, Human | |
| Datasheet | PD-L2 ELISA Kit, Human Datasheet |