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MBL Life Sciences
MBL Life Sciences
Academic users: Please submit a completed MTA form with your order to orders@cosmobiousa.com.
Commercial users: Please contact us at orders@cosmobiousa.com before placing an order. A license agreement with MBL International will need to be completed for ordering.
| Product Specifications | |
| Formulation | Dry form. Reconstitute with distilled water or TE before use. |
| Storage | -20C |
| Documents & Links for pFucci-G1 Orange (Expression vector) | |
| Datasheet | pFucci-G1 Orange (Expression vector) Datasheet |
| Purchase Agreement | pFucci-G1 Orange (Expression vector) Purchase Agreement |
| Documents & Links for pFucci-G1 Orange (Expression vector) | |
| Datasheet | pFucci-G1 Orange (Expression vector) Datasheet |
| Purchase Agreement | pFucci-G1 Orange (Expression vector) Purchase Agreement |
| Citations for pFucci-G1 Orange (Expression vector) – 33 Found |
| Newman, Robert H; Zhang, Jin. Fucci: street lights on the road to mitosis. Chemistry & Biology. 2008;15(2):97-8. PubMed |
| Sugiyama, Mayu; Sakaue-Sawano, Asako; Iimura, Tadahiro; Fukami, Kiyoko; Kitaguchi, Tetsuya; Kawakami, Koichi; Okamoto, Hitoshi; Higashijima, Shin-ichi; Miyawaki, Atsushi. Illuminating cell-cycle progression in the developing zebrafish embryo. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2009;106(49):20812-7. PubMed |
| Morikawa, Hanako; Kim, Minsoo; Mimuro, Hitomi; Punginelli, Claire; Koyama, Tomohiro; Nagai, Shinya; Miyawaki, Atsushi; Iwai, Kazuhiro; Sasakawa, Chihiro. The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1. Biochemical And Biophysical Research Communications. 2010;401(2):268-74. PubMed |
| Ogura, Yosuke; Sakaue-Sawano, Asako; Nakagawa, Masashi; Satoh, Nori; Miyawaki, Atsushi; Sasakura, Yasunori. Coordination of mitosis and morphogenesis: role of a prolonged G2 phase during chordate neurulation. Development (Cambridge, England). 2011;138(3):577-87. PubMed |
| Yang, Liangpeng; Kotomura, Naoe; Ho, Yik-Khuan; Zhi, Huijun; Bixler, Sandra; Schell, Michael J; Giam, Chou-Zen. Complex cell cycle abnormalities caused by human T-lymphotropic virus type 1 Tax. Journal Of Virology. 2011;85(6):3001-9. PubMed |
| Malka, Yuval; Eden, Sharon. Analysis of apoptosis in FUCCI HeLa cells. Cytometry. Part A : The Journal Of The International Society For Analytical Cytology. 2011;79(4):243-6. PubMed |
| Tofighi, Roshan; Wan Ibrahim, Wan Norhamidah; Rebellato, Paola; Andersson, Patrik L; Uhlén, Per; Ceccatelli, Sandra. Non-dioxin-like polychlorinated biphenyls interfere with neuronal differentiation of embryonic neural stem cells. Toxicological Sciences : An Official Journal Of The Society Of Toxicology. 2011;124(1):192-201. PubMed |
| Kaida, Atsushi; Miura, Masahiko. Visualizing the effect of hypoxia on fluorescence kinetics in living HeLa cells using the fluorescent ubiquitination-based cell cycle indicator (Fucci). Experimental Cell Research. 2012;318(3):288-97. PubMed |
| Dan, Shingo; Okamura, Mutsumi; Mukai, Yumiko; Yoshimi, Hisashi; Inoue, Yasumichi; Hanyu, Aki; Sakaue-Sawano, Asako; Imamura, Takeshi; Miyawaki, Atsushi; Yamori, Takao. ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo. European Journal Of Cancer (Oxford, England : 1990). 2012;48(6):936-43. PubMed |
| Downey, Mike J; Jeziorska, Danuta M; Ott, Sascha; Tamai, T Katherine; Koentges, Georgy; Vance, Keith W; Bretschneider, Till. Extracting fluorescent reporter time courses of cell lineages from high-throughput microscopy at low temporal resolution. Plos One. 6(12):e27886. PubMed |
| Ridenour, Dennis A; McKinney, Mary Cathleen; Bailey, Caleb M; Kulesa, Paul M. CycleTrak: a novel system for the semi-automated analysis of cell cycle dynamics. Developmental Biology. 2012;365(1):189-95. PubMed |
| Kaida, Atsushi; Miura, Masahiko. Differential dependence on oxygen tension during the maturation process between monomeric Kusabira Orange 2 and monomeric Azami Green expressed in HeLa cells. Biochemical And Biophysical Research Communications. 2012;421(4):855-9. PubMed |
| Ito, Sayuri; Ishii, Ai; Kakusho, Naoko; Taniyama, Chika; Yamazaki, Satoshi; Fukatsu, Rino; Sakaue-Sawano, Asako; Miyawaki, Atsushi; Masai, Hisao. Mechanism of cancer cell death induced by depletion of an essential replication regulator. Plos One. 7(5):e36372. PubMed |
| Hashimoto, T; Juso, K; Nakano, M; Nagano, T; Kambayashi, S; Nakashima, A; Kikkawa, U; Kamada, S. Preferential Fas-mediated apoptotic execution at G1 phase: the resistance of mitotic cells to the cell death. Cell Death & Disease. 2012;3(5):e313. PubMed |
| Abe, Takaya; Sakaue-Sawano, Asako; Kiyonari, Hiroshi; Shioi, Go; Inoue, Ken-ichi; Horiuchi, Toshitaka; Nakao, Kazuki; Miyawaki, Atsushi; Aizawa, Shinichi; Fujimori, Toshihiko. Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter. Development (Cambridge, England). 2013;140(1):237-46. PubMed |
| Coronado, Diana; Godet, Murielle; Bourillot, Pierre-Yves; Tapponnier, Yann; Bernat, Agnieszka; Petit, Maxime; Afanassieff, Marielle; Markossian, Suzy; Malashicheva, Anna; Iacone, Roberto; Anastassiadis, Konstantinos; Savatier, Pierre. A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency. Stem Cell Research. 2013;10(1):118-31. PubMed |
| Roccio, Marta; Schmitter, Daniel; Knobloch, Marlen; Okawa, Yuya; Sage, Daniel; Lutolf, Matthias P. Predicting stem cell fate changes by differential cell cycle progression patterns. Development (Cambridge, England). 2013;140(2):459-70. PubMed |
| Laurent, Jennifer; Frongia, Céline; Cazales, Martine; Mondesert, Odile; Ducommun, Bernard; Lobjois, Valérie. Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D. Bmc Cancer. 2013;13:73. PubMed |
| Equilibrina, I; Matsunaga, S; Morimoto, A; Hashimoto, T; Uchiyama, S; Fukui, K. ASURA (PHB2) interacts with Scc1 through chromatin. Cytogenetic And Genome Research. 139(4):225-33. PubMed |
| Bao, Yan; Mukai, Kuniaki; Hishiki, Takako; Kubo, Akiko; Ohmura, Mitsuyo; Sugiura, Yuki; Matsuura, Tomomi; Nagahata, Yoshiko; Hayakawa, Noriyo; Yamamoto, Takehiro; Fukuda, Ryo; Saya, Hideyuki; Suematsu, Makoto; Minamishima, Yoji Andrew. Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo. Molecular Cancer Research : Mcr. 2013;11(9):973-85. PubMed |
| Nagano, Taiki; Hashimoto, Toshiaki; Nakashima, Akio; Hisanaga, Shin-ichi; Kikkawa, Ushio; Kamada, Shinji. Cyclin I is involved in the regulation of cell cycle progression. Cell Cycle (Georgetown, Tex.). 2013;12(16):2617-24. PubMed |
| Bouchard, G; Bouvette, G; Therriault, H; Bujold, R; Saucier, C; Paquette, B. Pre-irradiation of mouse mammary gland stimulates cancer cell migration and development of lung metastases. British Journal Of Cancer. 2013;109(7):1829-38. PubMed |
| Tomura, Michio; Sakaue-Sawano, Asako; Mori, Yoshiko; Takase-Utsugi, Mitsuyo; Hata, Akihiro; Ohtawa, Kenji; Kanagawa, Osami; Miyawaki, Atsushi. Contrasting quiescent G0 phase with mitotic cell cycling in the mouse immune system. Plos One. 8(9):e73801. PubMed |
| Pauklin, Siim; Vallier, Ludovic. The cell-cycle state of stem cells determines cell fate propensity. Cell. 2013;155(1):135-47. PubMed |
| Sakaue-Sawano, Asako; Hoshida, Tetsushi; Yo, Masahiro; Takahashi, Reiko; Ohtawa, Kenji; Arai, Takashi; Takahashi, Eiki; Noda, Shinichi; Miyoshi, Hiroyuki; Miyawaki, Atsushi. Visualizing developmentally programmed endoreplication in mammals using ubiquitin oscillators. Development (Cambridge, England). 2013;140(22):4624-32. PubMed |
| Singh, Amar M; Chappell, James; Trost, Robert; Lin, Li; Wang, Tao; Tang, Jie; Matlock, Brittany K; Weller, Kevin P; Wu, Hao; Zhao, Shaying; Jin, Peng; Dalton, Stephen. Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Reports. 1(6):532-44. PubMed |
| Paladino, Patrick; Marcon, Edyta; Greenblatt, Jack; Frappier, Lori. Identification of herpesvirus proteins that contribute to G1/S arrest. Journal Of Virology. 2014;88(8):4480-92. PubMed |
| Dowling, Mark R; Kan, Andrey; Heinzel, Susanne; Zhou, Jie H S; Marchingo, Julia M; Wellard, Cameron J; Markham, John F; Hodgkin, Philip D. Stretched cell cycle model for proliferating lymphocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2014;111(17):6377-82. PubMed |
| Nahar, Kamrun; Goto, Tatsuaki; Kaida, Atsushi; Deguchi, Shifumi; Miura, Masahiko. Effects of Chk1 inhibition on the temporal duration of radiation-induced G2 arrest in HeLa cells. Journal Of Radiation Research. 2014;55(5):1021-7. PubMed |
| Carlier, Géraldine; Maugein, Alicia; Cordier, Corinne; Pechberty, Séverine; Garfa-Traoré, Meriem; Martin, Patrick; Scharfmann, Raphaël; Albagli, Olivier. Human fucci pancreatic Beta cell lines: new tools to study Beta cell cycle and terminal differentiation. Plos One. 9(9):e108202. PubMed |
| Jin, Sha; Cordes, Nils. ATM controls DNA repair and mitochondria transfer between neighboring cells. Cell Communication And Signaling : Ccs. 2019;17(1):144. PubMed |
| Matsumoto, Yasunori; Kano, Masayuki; Murakami, Kentaro; Toyozumi, Takeshi; Suito, Hiroshi; Takahashi, Masahiko; Sekino, Nobufumi; Shiraishi, Tadashi; Kamata, Toshiki; Ryuzaki, Takahiro; Hirasawa, Soichiro; Kinoshita, Kazuya; Matsubara, Hisahiro. Tumor-derived exosomes influence the cell cycle and cell migration of human esophageal cancer cell lines. Cancer Science. 2020;111(12):4348-4358. PubMed |
| Matsumoto, Daisuke; Tamamura, Hirokazu; Nomura, Wataru. A cell cycle-dependent CRISPR-Cas9 activation system based on an anti-CRISPR protein shows improved genome editing accuracy. Communications Biology. 2020;3(1):601. PubMed |
Material Transfer or Licensing Agreement (MTA)
The manufacturer of this product requires a signed Material Transfer or Licensing Agreement to be submitted at time of order placement. Access the agreement in the Documents section below. Please download and fill in the document as requested. Submit the completed document with your order to orders@cosmobiousa.com.
Academic users: Please submit a completed MTA form with your order to orders@cosmobiousa.com.
Commercial users: Please contact us at orders@cosmobiousa.com before placing an order. A license agreement with MBL International will need to be completed for ordering.
| Product Specifications | |
| Formulation | Dry form. Reconstitute with distilled water or TE before use. |
| Storage | -20C |
| Documents & Links for pFucci-G1 Orange (Expression vector) | |
| Datasheet | pFucci-G1 Orange (Expression vector) Datasheet |
| Purchase Agreement | pFucci-G1 Orange (Expression vector) Purchase Agreement |
| Documents & Links for pFucci-G1 Orange (Expression vector) | |
| Datasheet | pFucci-G1 Orange (Expression vector) Datasheet |
| Purchase Agreement | pFucci-G1 Orange (Expression vector) Purchase Agreement |
| Citations for pFucci-G1 Orange (Expression vector) – 33 Found |
| Newman, Robert H; Zhang, Jin. Fucci: street lights on the road to mitosis. Chemistry & Biology. 2008;15(2):97-8. PubMed |
| Sugiyama, Mayu; Sakaue-Sawano, Asako; Iimura, Tadahiro; Fukami, Kiyoko; Kitaguchi, Tetsuya; Kawakami, Koichi; Okamoto, Hitoshi; Higashijima, Shin-ichi; Miyawaki, Atsushi. Illuminating cell-cycle progression in the developing zebrafish embryo. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2009;106(49):20812-7. PubMed |
| Morikawa, Hanako; Kim, Minsoo; Mimuro, Hitomi; Punginelli, Claire; Koyama, Tomohiro; Nagai, Shinya; Miyawaki, Atsushi; Iwai, Kazuhiro; Sasakawa, Chihiro. The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1. Biochemical And Biophysical Research Communications. 2010;401(2):268-74. PubMed |
| Ogura, Yosuke; Sakaue-Sawano, Asako; Nakagawa, Masashi; Satoh, Nori; Miyawaki, Atsushi; Sasakura, Yasunori. Coordination of mitosis and morphogenesis: role of a prolonged G2 phase during chordate neurulation. Development (Cambridge, England). 2011;138(3):577-87. PubMed |
| Yang, Liangpeng; Kotomura, Naoe; Ho, Yik-Khuan; Zhi, Huijun; Bixler, Sandra; Schell, Michael J; Giam, Chou-Zen. Complex cell cycle abnormalities caused by human T-lymphotropic virus type 1 Tax. Journal Of Virology. 2011;85(6):3001-9. PubMed |
| Malka, Yuval; Eden, Sharon. Analysis of apoptosis in FUCCI HeLa cells. Cytometry. Part A : The Journal Of The International Society For Analytical Cytology. 2011;79(4):243-6. PubMed |
| Tofighi, Roshan; Wan Ibrahim, Wan Norhamidah; Rebellato, Paola; Andersson, Patrik L; Uhlén, Per; Ceccatelli, Sandra. Non-dioxin-like polychlorinated biphenyls interfere with neuronal differentiation of embryonic neural stem cells. Toxicological Sciences : An Official Journal Of The Society Of Toxicology. 2011;124(1):192-201. PubMed |
| Kaida, Atsushi; Miura, Masahiko. Visualizing the effect of hypoxia on fluorescence kinetics in living HeLa cells using the fluorescent ubiquitination-based cell cycle indicator (Fucci). Experimental Cell Research. 2012;318(3):288-97. PubMed |
| Dan, Shingo; Okamura, Mutsumi; Mukai, Yumiko; Yoshimi, Hisashi; Inoue, Yasumichi; Hanyu, Aki; Sakaue-Sawano, Asako; Imamura, Takeshi; Miyawaki, Atsushi; Yamori, Takao. ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo. European Journal Of Cancer (Oxford, England : 1990). 2012;48(6):936-43. PubMed |
| Downey, Mike J; Jeziorska, Danuta M; Ott, Sascha; Tamai, T Katherine; Koentges, Georgy; Vance, Keith W; Bretschneider, Till. Extracting fluorescent reporter time courses of cell lineages from high-throughput microscopy at low temporal resolution. Plos One. 6(12):e27886. PubMed |
| Ridenour, Dennis A; McKinney, Mary Cathleen; Bailey, Caleb M; Kulesa, Paul M. CycleTrak: a novel system for the semi-automated analysis of cell cycle dynamics. Developmental Biology. 2012;365(1):189-95. PubMed |
| Kaida, Atsushi; Miura, Masahiko. Differential dependence on oxygen tension during the maturation process between monomeric Kusabira Orange 2 and monomeric Azami Green expressed in HeLa cells. Biochemical And Biophysical Research Communications. 2012;421(4):855-9. PubMed |
| Ito, Sayuri; Ishii, Ai; Kakusho, Naoko; Taniyama, Chika; Yamazaki, Satoshi; Fukatsu, Rino; Sakaue-Sawano, Asako; Miyawaki, Atsushi; Masai, Hisao. Mechanism of cancer cell death induced by depletion of an essential replication regulator. Plos One. 7(5):e36372. PubMed |
| Hashimoto, T; Juso, K; Nakano, M; Nagano, T; Kambayashi, S; Nakashima, A; Kikkawa, U; Kamada, S. Preferential Fas-mediated apoptotic execution at G1 phase: the resistance of mitotic cells to the cell death. Cell Death & Disease. 2012;3(5):e313. PubMed |
| Abe, Takaya; Sakaue-Sawano, Asako; Kiyonari, Hiroshi; Shioi, Go; Inoue, Ken-ichi; Horiuchi, Toshitaka; Nakao, Kazuki; Miyawaki, Atsushi; Aizawa, Shinichi; Fujimori, Toshihiko. Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter. Development (Cambridge, England). 2013;140(1):237-46. PubMed |
| Coronado, Diana; Godet, Murielle; Bourillot, Pierre-Yves; Tapponnier, Yann; Bernat, Agnieszka; Petit, Maxime; Afanassieff, Marielle; Markossian, Suzy; Malashicheva, Anna; Iacone, Roberto; Anastassiadis, Konstantinos; Savatier, Pierre. A short G1 phase is an intrinsic determinant of naïve embryonic stem cell pluripotency. Stem Cell Research. 2013;10(1):118-31. PubMed |
| Roccio, Marta; Schmitter, Daniel; Knobloch, Marlen; Okawa, Yuya; Sage, Daniel; Lutolf, Matthias P. Predicting stem cell fate changes by differential cell cycle progression patterns. Development (Cambridge, England). 2013;140(2):459-70. PubMed |
| Laurent, Jennifer; Frongia, Céline; Cazales, Martine; Mondesert, Odile; Ducommun, Bernard; Lobjois, Valérie. Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D. Bmc Cancer. 2013;13:73. PubMed |
| Equilibrina, I; Matsunaga, S; Morimoto, A; Hashimoto, T; Uchiyama, S; Fukui, K. ASURA (PHB2) interacts with Scc1 through chromatin. Cytogenetic And Genome Research. 139(4):225-33. PubMed |
| Bao, Yan; Mukai, Kuniaki; Hishiki, Takako; Kubo, Akiko; Ohmura, Mitsuyo; Sugiura, Yuki; Matsuura, Tomomi; Nagahata, Yoshiko; Hayakawa, Noriyo; Yamamoto, Takehiro; Fukuda, Ryo; Saya, Hideyuki; Suematsu, Makoto; Minamishima, Yoji Andrew. Energy management by enhanced glycolysis in G1-phase in human colon cancer cells in vitro and in vivo. Molecular Cancer Research : Mcr. 2013;11(9):973-85. PubMed |
| Nagano, Taiki; Hashimoto, Toshiaki; Nakashima, Akio; Hisanaga, Shin-ichi; Kikkawa, Ushio; Kamada, Shinji. Cyclin I is involved in the regulation of cell cycle progression. Cell Cycle (Georgetown, Tex.). 2013;12(16):2617-24. PubMed |
| Bouchard, G; Bouvette, G; Therriault, H; Bujold, R; Saucier, C; Paquette, B. Pre-irradiation of mouse mammary gland stimulates cancer cell migration and development of lung metastases. British Journal Of Cancer. 2013;109(7):1829-38. PubMed |
| Tomura, Michio; Sakaue-Sawano, Asako; Mori, Yoshiko; Takase-Utsugi, Mitsuyo; Hata, Akihiro; Ohtawa, Kenji; Kanagawa, Osami; Miyawaki, Atsushi. Contrasting quiescent G0 phase with mitotic cell cycling in the mouse immune system. Plos One. 8(9):e73801. PubMed |
| Pauklin, Siim; Vallier, Ludovic. The cell-cycle state of stem cells determines cell fate propensity. Cell. 2013;155(1):135-47. PubMed |
| Sakaue-Sawano, Asako; Hoshida, Tetsushi; Yo, Masahiro; Takahashi, Reiko; Ohtawa, Kenji; Arai, Takashi; Takahashi, Eiki; Noda, Shinichi; Miyoshi, Hiroyuki; Miyawaki, Atsushi. Visualizing developmentally programmed endoreplication in mammals using ubiquitin oscillators. Development (Cambridge, England). 2013;140(22):4624-32. PubMed |
| Singh, Amar M; Chappell, James; Trost, Robert; Lin, Li; Wang, Tao; Tang, Jie; Matlock, Brittany K; Weller, Kevin P; Wu, Hao; Zhao, Shaying; Jin, Peng; Dalton, Stephen. Cell-cycle control of developmentally regulated transcription factors accounts for heterogeneity in human pluripotent cells. Stem Cell Reports. 1(6):532-44. PubMed |
| Paladino, Patrick; Marcon, Edyta; Greenblatt, Jack; Frappier, Lori. Identification of herpesvirus proteins that contribute to G1/S arrest. Journal Of Virology. 2014;88(8):4480-92. PubMed |
| Dowling, Mark R; Kan, Andrey; Heinzel, Susanne; Zhou, Jie H S; Marchingo, Julia M; Wellard, Cameron J; Markham, John F; Hodgkin, Philip D. Stretched cell cycle model for proliferating lymphocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America. 2014;111(17):6377-82. PubMed |
| Nahar, Kamrun; Goto, Tatsuaki; Kaida, Atsushi; Deguchi, Shifumi; Miura, Masahiko. Effects of Chk1 inhibition on the temporal duration of radiation-induced G2 arrest in HeLa cells. Journal Of Radiation Research. 2014;55(5):1021-7. PubMed |
| Carlier, Géraldine; Maugein, Alicia; Cordier, Corinne; Pechberty, Séverine; Garfa-Traoré, Meriem; Martin, Patrick; Scharfmann, Raphaël; Albagli, Olivier. Human fucci pancreatic Beta cell lines: new tools to study Beta cell cycle and terminal differentiation. Plos One. 9(9):e108202. PubMed |
| Jin, Sha; Cordes, Nils. ATM controls DNA repair and mitochondria transfer between neighboring cells. Cell Communication And Signaling : Ccs. 2019;17(1):144. PubMed |
| Matsumoto, Yasunori; Kano, Masayuki; Murakami, Kentaro; Toyozumi, Takeshi; Suito, Hiroshi; Takahashi, Masahiko; Sekino, Nobufumi; Shiraishi, Tadashi; Kamata, Toshiki; Ryuzaki, Takahiro; Hirasawa, Soichiro; Kinoshita, Kazuya; Matsubara, Hisahiro. Tumor-derived exosomes influence the cell cycle and cell migration of human esophageal cancer cell lines. Cancer Science. 2020;111(12):4348-4358. PubMed |
| Matsumoto, Daisuke; Tamamura, Hirokazu; Nomura, Wataru. A cell cycle-dependent CRISPR-Cas9 activation system based on an anti-CRISPR protein shows improved genome editing accuracy. Communications Biology. 2020;3(1):601. PubMed |
Material Transfer or Licensing Agreement (MTA)
The manufacturer of this product requires a signed Material Transfer or Licensing Agreement to be submitted at time of order placement. Access the agreement in the Documents section below. Please download and fill in the document as requested. Submit the completed document with your order to orders@cosmobiousa.com.